Endocrine Abstracts

Background: Papillary thyroid cancer (PTC) is a disease with an indolent course, excellent overall prognosis and long-term survival. However, some PTCs are associated with an increased risk of recurrent disease and aggressive behaviour. Many exogenous factors, as obesity, could be implicated in the pathogenesis of thyroid cancer but the biological mechanisms that may explain this connection have been only partially described. Potentially factors that combine overweight with th...

Objective: Currently, data about the molecular profile of multifocal papillary thyroid cancer (PTC) are still controversial. The aim of this study was to fully characterize by NGS the molecular profile of different histological variants in patients affected by multifocal PTCs.Methods: for this purpose, 12 multifocal PTC patients have been studied based to the following inclusion criteria: 1) a minimum of two tumors foci per patient with at least two diff...